Derivatives of amidines, their preparation, their use as medicaments and the pharmaceutical compositions containing them

US7473779B2 · kind B2 · utility

Assignee

• Société de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS · FR

Inventors

• Serge Auvin · Mauchamps, FR
• Pierre-Etienne Chabrier de Lassauniere · Paris, FR
• Jeremiah Harnett · Gif-sur-Yvette, FR
• Dominique Pons · Paris, FR
• Gerard Ulibarri · Les Ulis, FR

Key dates

• Filing date: Sep 12, 2003
• Grant date: Jan 6, 2009
• Expiry date: Jan 14, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel derivatives of amidines of formulawherein the substituents are defined as in the specification which are useful for inhibiting activity on NO-synthase enzymes producing nitrogen mono oxide and/or trapping the reactive oxygen species (ROS) making them useful for treating various diseases.