Methods to engineer stratified cartilage tissue
US7476257B2 · kind B2 · utility
26Cited by
65References
18Claims
0Family size
Assignees
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Key dates
| Filing date | Sep 13, 2002 |
| Grant date | Jan 13, 2009 |
| Priority date | — |
| Expiry date | Sep 28, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2509/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to a cultured, stratified cartilage tissue that comprises a tissue-engineered, cohesive cartilage construct comprised of two or more cartilage layers, wherein each cartilage layer comprises chondrogenic cells having a chondrocytic phenotype corresponding to chondrocytes present in: a superficial-tangential zone of natural cartilage; a middle-transitional zone of natural cartilage; a deep-radial zone of natural cartilage; or a calcified cartilage zone of natural cartilage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.