Dbait and uses thereof

US7476729B2 · kind B2 · utility

Assignees

• INSTITUT CURIE · FR
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• MUSEUM NATIONAL D'HISTOIRE NATURELLE · FR
• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventors

• Marie Dutreix · L'Haÿ-les-Roses, FR
• Jian Sun · Saint-Maur-des-Fossés, FR

Key dates

• Filing date: Sep 21, 2006
• Grant date: Jan 13, 2009
• Expiry date: Sep 21, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses novel double-stranded nucleic acid molecules that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non homologous end joining (NHEJ) pathway of DSB repair. The invention discloses the use of these molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumor cell nuclei in order to neutralize transiently their DNA repair capacity and trigger their death.