Humanized anti-ghrelin antibodies
US7479271B2 · kind B2 · utility
4Cited by
0References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 9, 2006 |
| Grant date | Jan 20, 2009 |
| Priority date | — |
| Expiry date | Feb 9, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Humanized antibodies, or antigen-binding portions thereof, that preferentially bind acylated ghrelin with respect to unacylated ghrelin, are disclosed. These molecules have high affinity and a slow off rate for acylated ghrelin, and neutralize acylated ghrelin activity. These antibodies, or antigen-binding portions thereof, are useful for neutralizing acylated ghrelin activity, e.g., in a subject suffering from a disorder in which ghrelin activity is detrimental, such as obesity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.