Troponin I polypeptide fragments and uses thereof
US7479278B2 · kind B2 · utility
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Key dates
| Filing date | Aug 29, 2001 |
| Grant date | Jan 20, 2009 |
| Priority date | — |
| Expiry date | Aug 29, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polypeptides corresponding to stable, circulating degradation products of troponin I (TnI) are described. The fragments comprise a sequence of the N-terminus of native cardiac TnI with 95-115 amino acid and additionally include fragments lacking about the 20-30 N-terminal amino acids. Utilities of these fragments and antibodies thereto include sensitive detection of myocardial infarction and purification of antibodies sensitive to the detection of troponin I degradation products.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.