Reagents and methods useful for detecting diseases of the breast

US7479537B2 · kind B2 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Patricia Billing-Medel · Gurnee, US
• Maurice Cohen · Miami, US
• Tracey Colpitts · Round Lake, US
• Paula Friedman · Deerfield, US
• Julian Gordon · Lake Bluff, US
• Edward Granados · Vernon Hills, US
• Steven Hodges · Buffalo Grove, US
• Michael Klass · Libertyville, US
• Jon Kratochvil · Wildwood, US
• Lisa Roberts-Rapp · Gurnee, US
• John Russell · Pleasant Prairie, US
• Stephen D. Stroupe · Libertyville, US

Key dates

• Filing date: May 11, 2005
• Grant date: Jan 20, 2009
• Expiry date: Dec 31, 2025

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.