Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions

US7482337B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Frank Himmelsbach · Mittelbiberach, DE
• Elke Langkopf · Biberach an der Riß, DE
• Matthias Eckhardt · Hannover, DE
• Roland Maier · Biberach an der Riß, DE
• Michael Mark · Biberach an der Riß, DE
• Mohammad Tadayyon · Hertford, GB
• Ralf Lotz · Schemmerhofen, DE

Key dates

• Filing date: Oct 28, 2003
• Grant date: Jan 27, 2009
• Expiry date: Oct 28, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P3/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are substituted xanthines of general formulawherein R1 to R4 are defined hereinbelow, the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).