Positive modulator of bone morphogenic protein-2
US7482427B2 · kind B2 · utility
16Cited by
53References
8Claims
0Family size
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Key dates
| Filing date | Feb 22, 2005 |
| Grant date | Jan 27, 2009 |
| Priority date | — |
| Expiry date | Dec 3, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.