Patent · US Active

Protease inhibitor conjugates and antibodies useful in immunoassay

US7482437B2 · kind B2 · utility

0Cited by

2References

6Claims

0Family size

Assignee

Roche Diagnostics Operations, Inc. · US

Inventors

Gerald Sigler · Carmel, US
Raymond Hui · Indianapolis, US
Ina Deras · San Diego, US
Richard Root · Fishers, US
Mitali Ghoshal · Noblesville, US
Erasmus Huber · Garching bei München, DE
Herbert von der Eltz · Spaichingen, DE
Sigrun Metz · Munich, DE
Peter Kern · Penzberg, DE

Key dates

Filing date	Feb 2, 2007
Grant date	Jan 27, 2009
Priority date	—
Expiry date	Feb 2, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K16/44
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.