Patent · US Active

N-thiolated 2-oxazolidinone-derived antibiotics

US7482467B2 · kind B2 · utility

1Cited by

4References

13Claims

0Family size

Assignee

University of South Florida · US

Inventors

Edward Turos · Tampa, US
Rajesh Kumar Mishra · Needham, US

Key dates

Filing date	Nov 30, 2007
Grant date	Jan 27, 2009
Priority date	—
Expiry date	Nov 30, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D263/52
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by Ndeprotection and N-sulfenylation. These new substances were found to exhibit potent anti-bacterial activity, including bacteriostatic properties against Staphylococcus spp., including methicillin resistant Staphylococcus aureus (MRSA), and Bacillus spp., including Bacillus anthracis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.