Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
US7485291B2 · kind B2 · utility
14Cited by
36References
20Claims
0Family size
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Key dates
| Filing date | Jun 3, 2003 |
| Grant date | Feb 3, 2009 |
| Priority date | — |
| Expiry date | Jun 3, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/203
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Single vector constructs for expression of a functional antibody molecule are described. The vectors have a self-processing cleavage site between two heterologous DNA coding sequences allowing for expression of two coding sequences using a single promoter. Exemplary vector constructs comprise a foot and mouth disease virus (FMDV) 2A sequence. The vector constructs can be used in methods relating to antibody delivery and therapy and in the production of a biologically active antibody or fragment thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.