Oral microemulsion composition comprising biphenyldimethyldicarboxylate and silybin
US7485326B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Oct 21, 2004 |
| Grant date | Feb 3, 2009 |
| Priority date | — |
| Expiry date | Aug 9, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/4858
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A microemulsion composition comprising biphenyldimethyldicarboxylate (BDD) and silybin or a derivative thereof, or a <i>Carduus marianus</i> extract containing silybin and derivatives thereof, as active ingredients; a co-surfactant; a surfactant; and an oil provides a synergistic therapeutic effect for liver diseases due to the complementary work of the two kinds of active ingredients having different working mechanisms without any adverse side effect or an antagonism, and high <i>in vivo</i> bioavailabilities of both of the active ingredients, when orally administered.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.