Stable retrovirus and methods of use
US7485446B2 · kind B2 · utility
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1Claims
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Key dates
| Filing date | Feb 21, 2007 |
| Grant date | Feb 3, 2009 |
| Priority date | — |
| Expiry date | Feb 21, 2027 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/221
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is a mutant retroviral protease which confers an increase in retroviral stability. Retroviruses expressing the instant mutant retroviral protease exhibit at least a 2-fold increase in infectivity half-life as compared to wild-type retrovirus. Unexpectedly, a Gly119Glu mutation in the protease enhances retroviral stability in the presence of various wild-type envelope proteins including wild-type amphotropic, ecotropic and 10A1 murine leukemia viruses. The improved stability of the mutant retrovirus leads to more facile virus production and enhanced infection efficiency.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.