Methods and compositions for treatment of inflammatory disease using cadherin-11 modulating agents
US7488478B2 · kind B2 · utility
3Cited by
12References
7Claims
0Family size
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Key dates
| Filing date | Aug 31, 2005 |
| Grant date | Feb 10, 2009 |
| Priority date | — |
| Expiry date | Aug 31, 2025 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for treating inflammatory joint diseases by inhibiting cadherin-11 mediated cellular function using a cadherin-11 modulating agent is provided. Also provided are screening assays for identifying pharmaceutical lead compounds capable of modulating cellular functions of cadherin-11 such as cell proliferation, apoptosis, factor secretion, and binding of cadherin-11 to cadherin-11 counter-receptor inhibiting binding of cadherin-11 to its counter-receptor either in the context of a cell or in soluble form.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.