Polypeptides derived from anti-HIV-1 gp120 antibodies that abrogate gp120 binding to CCR5
US7488481B2 · kind B2 · utility
2Cited by
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15Claims
0Family size
Assignee
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Key dates
| Filing date | Feb 5, 2004 |
| Grant date | Feb 10, 2009 |
| Priority date | — |
| Expiry date | Aug 13, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to peptides that are capable of blocking the entry of HIV-1 into host cells by means of the CCR5 receptor. The affinity of the peptides for gp120 on the HIV viral surface may be increased by sulfating tyrosine residues. In addition, the invention is directed to a method for increasing the affinity of antibodies for their antigens by sulfating tyrosine residues in the antibody amino acid chain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.