6-arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors

US7488733B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Martin Hendrix · Tarrytown, US
• Lars Bärfacker · Oberhausen, DE
• Bettina Beyreuther · Mülheim an der Ruhr, DE
• Ulrich Ebert · Mannheim, DE
• Christina Erb · Wiesbaden, DE
• Frank-Thorsten Hafner · Wuppertal, DE
• Heike Heckroth · Wuppertal, DE
• Yan Liu · San Diego, US
• Dagmar Karthaus · Solingen, DE
• Adrian Tersteegen · Wuppertal, DE
• Franz-Josef van der Staay · Dronten, NL
• Marja Van Kampen · Neu-Isenburg, DE

Key dates

• Filing date: Jun 16, 2004
• Grant date: Feb 10, 2009
• Expiry date: Jun 16, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I)methods for the production thereof, and the use thereof for producing medicaments utilized for improving awareness, concentration, learning capacity, and/or retentiveness of memory. Said compounds (I) show activity as PDE9 inhibitors.