Human antibodies to human delta like ligand 4

US7488806B2 · kind B2 · utility

Assignee

• REGENERON PHARMACEUTICALS, INC. · US

Inventors

• Nicholas J. Papadopoulos · Lagrangeville, US
• Joel H. Martin · Putnam Valley, US
• Eric Smith · New York, US
• Irene Noguera-Troise · Bay Shore, US
• Gavin Thurston · Briarcliff Manor, US

Key dates

• Filing date: Oct 3, 2008
• Grant date: Feb 10, 2009
• Expiry date: Oct 3, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDll4) and blocks hDll4 binding to a Notch receptor. The human anti-hDll4 antibody or antibody fragment binds hDll4 with an affinity of 300 pM or better, as measured by surface plasmon resonance.