Method for producing 2-chloromethylphenyl acetic acid derivatives

US7488840B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Guido Mayer · Neheim, DE
• Oliver Cullmann · Mannheim, DE
• Bernd Wolf · Niederkirchen, DE
• Michael Keil · Freinsheim, DE
• Wassilios Grammenos · Ludwigshafen, DE

Key dates

• Filing date: Feb 6, 2003
• Grant date: Feb 10, 2009
• Expiry date: Dec 26, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C249/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a method for producing 2-chloromethylphenyl acetic acid derivatives of formula (I), in which X represents C1-C4 alkoxy or methylamino, by cleaving the ether bonds in compounds of formula (II), in which R represents C1-C4 alkyl, C1-C4 alkoxy, C1-C2 alkyl halide, C1-C4 alkylcarbonyl, C1-C4 alkylcarbonyloxy, halogen, nitro or cyano, and X has the above-mentioned meaning. The inventive method is characterized in that the transformation takes place in the presence of hydrogen chloride and of an inert solvent, and in that a catalyst selected from the group comprised of: iron, indium or halogenides, oxides or triflates thereof is added to the reaction mixture.