Automatic infusion system based on an adaptive patient model

US7491187B2 · kind B2 · utility

Assignee

• K.U. Leuven Research & Development · BE

Inventors

• Greta Van Den Berghe · Leuven, BE
• Daniel Berckmans · Kessel-Lo, BE
• Jean-Marie Aerts · Haasrode, BE
• Bart De Moor · Bierbeek, BE
• Bert Pluymers · Leuven, BE
• Frank De Smet · Mechelen, BE

Key dates

• Filing date: Mar 24, 2003
• Grant date: Feb 17, 2009
• Expiry date: Jan 1, 2024

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2230/201
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Present invention is a system of blood glucose monitoring and intensive insulin therapy in a ICU for strict maintenance of normoglycemia which reduces intensive care and hospital mortality and morbidity of critically ill adult patients. The findings of present study also reveal factors determining insulin doses needed to maintain normoglycemia as well as the impact of insulin dose versus blood glucose level on the observed outcome benefits have been established. The invention provides a control system that adapts the flow of the insulin infusion based on insulin requirement calculated by blood glucose levels and clinical parameters such as history of diabetes, Body Mass Index, blood glucose level on admission, reason of ICU admission, time in the ICU, type and severity of illness, caloric intake, obesity, drugs affecting insulin sensitivity). This automated insulin monitoring systems significantly reduces the workload and human resource management problems for intensive insulin therapy in patients in the ICU.