Process for the preparation of hypoallergenic mosaic antigens

US7491396B2 · kind B2 · utility

Assignee

• BIOMAY AG · AT

Inventors

• Nadine Mothes · Sollenau, AT
• Sabine Stumvoll · Spittal an der Drau, AT
• Margit Focke · Wien, AT
• Birgit Linhart · Neunkirchen, AT
• Maria-Theresa Krauth · Tribuswinkel, AT
• Peter Valent · Wien, AT
• Dietrich Kraft · Wien, AT
• Rudolf Valenta · Theresienfeld, AT

Key dates

• Filing date: Dec 18, 2003
• Grant date: Feb 17, 2009
• Expiry date: Sep 15, 2024

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for the preparation of an hypoallergenic mosaic antigen derived from an allergen is disclosed whereby a) in a first step the allergen is split into at least two parts and the IgE reactivity of each part is determined and b) in a second step those parts of the allergen which have no detectable IgE reaction are combined to a mosaic antigen which comprises the amino acids of the allergen but the order of the amino acids of the mosaic antigen is different from that of the naturally occurring allergen.