Cytomegalovirus disintegrin-like peptides
US7491490B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | May 12, 2005 |
| Grant date | Feb 17, 2009 |
| Priority date | — |
| Expiry date | Nov 24, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/16134
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods and compositions for inhibiting the entry of viruses, such as herpesviruses into a host cell. A conserved viral integrin-binding gB disintegrin-like domain has been identified that engages integrins and facilitates viral internalization into the host cell. Therefore, methods and compositions, such as antiviral agents encompassing the conserved gB disintegrin-like domain and antibodies thereto are described. These active agents interfere with the interaction between virions and cellular integrins, thereby inhibiting viral infection of a host cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.