Diagnostics and therapeutics for diseases associated with Neuromedin U2 receptor (NMU2)

US7491550B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Stefan Golz · Wetter (Ruhr), DE
• Ulf Bruggemeier · Leichlingen, DE
• Andreas Geerts · Wuppertal, DE

Key dates

• Filing date: May 14, 2003
• Grant date: Feb 17, 2009
• Expiry date: Jun 22, 2023

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/04
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention provides a human NMU2 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, cancer, genitourinary diseases and respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, cancer, genitourinary diseases and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of NMU2 as well as pharmaceutical compositions comprising such compounds.