Synthetic lipid-a-analogs and uses thereof
US7491707B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 15, 2000 |
| Grant date | Feb 17, 2009 |
| Priority date | — |
| Expiry date | Nov 15, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/812
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New synthetic Lipid-A analogs based on monosaccharide (1) and disaccharide (2) derivatives were designed and prepared in the present invention. Both structures (1) and (2) incorporate novel lipid structures (3) and (4) that are not found in nature. Also, novel disaccharide Lipid-A structures (2) that incorporate novel contingents of uniform lipids and where R1, R4 and R5 are the same substitution group of structure (III) were synthesized. Liposome formulations containing totally synthetic components such as synthetic Lipid-A and synthetic lipopeptide derived from tumor-associated MUC1 mucin are described along with their therapeutic utility. Comparative test results of immunostimulating properties and toxicity of Lipid-A analogs (1) and (2) are included.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.