3-Substituted 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof

US7491729B2 · kind B2 · utility

Assignee

• Abbott GmbH & Co. KG · DE

Inventors

• Margaretha Henrica Maria Bakker · Ludwigshafen, DE
• Wilfried Hornberger · Wiesbaden, DE
• Andreas Kling · Mannheim, DE
• Udo Lange · Ludwigshafen, DE
• Helmut Mack · Ludwigshafen, DE
• Achim Moeller · Grünstadt, DE
• Reinhold Mueller · Schifferstadt, DE
• Kurt Schellhaas · Ludwigshafen, DE
• Martin Schmidt · Frankfurt am Main, DE
• Gerd Steiner · Tauberbischofsheim, DE
• Karsten Wicke · Ludwigshafen, DE

Key dates

• Filing date: Dec 17, 2003
• Grant date: Feb 17, 2009
• Expiry date: Dec 21, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

3-Substituted 3,4-dihydrothieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof. The invention relates to 3,4-dihydrothieno[2,3-d]pyrimidin-4-one derivatives which are substituted in position 3 by 5-membered heteroaryl which may be fused to an aryl or heteroaryl radical, where the heteroaryl and, if appropriate, the fused aryl or heteroaryl radical may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2, —NH(R6), aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl, where the substituents aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl may have 1, 2 or 3 substituents selected independently of one another from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halo-C1-5-alkyl, halo-C1-5-alkoxy, hydroxy, —NH2, —N(R6)2 and —NH(R6). The preparation and use of these derivatives, especially for therapeutic purposes, e.g. for the treatment of depressions, are likewise described.