Non-ionic surfactants for poorly soluble molecules

US7491836B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Christian VON CORSWANT · Mölndal, SE
• Karl Hult · Stockholm, SE
• Erik William Soderlind · Lakeside, US
• Fredrik Viklund · Stockholm, SE

Key dates

• Filing date: Apr 13, 2004
• Grant date: Feb 17, 2009
• Expiry date: Sep 15, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P7/62
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New non-ionic surfactants in the form of polyoxyalkylene glycol hydroxy fatty acid derivatives or monoalkylated polyoxyalkylene glycol hydroxy fatty acid derivatives having a polyoxyalkylene/alkyl polyoxyalkylene chain with a chain-length of 25-455 repeating units and a specified substituent on the hydroxy position of the specified hydroxy fatty acid, according to the general formula (I) CH3—(CH2)x—CH—(CH2)y—CO—[—O—R3—]z—O—R1 R2—O (I); wherein for example R1 is methyl, R2 is optionally substituted C14-C22 acyl, alkyl, or alkenyl, R3 is ethylene, x is 2-12, y is 7-17, (x+y) is 3-19 and z is 25-57; advantageously prepared by involving an enzymatic process, formulations comprising them, their use as solubilizers and a process involving a hydrolytic enzyme for preparing them.