Antibodies and molecules derived therefrom that bind to STEAP-1 proteins
US7494646B2 · kind B2 · utility
32Cited by
4References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 23, 2004 |
| Grant date | Feb 24, 2009 |
| Priority date | — |
| Expiry date | Sep 14, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.