Immunizing composition and method for inducing an immune response against the β-secretase cleavage site of amyloid precursor protein
US7494655B2 · kind B2 · utility
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5References
34Claims
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Key dates
| Filing date | Mar 4, 2003 |
| Grant date | Feb 24, 2009 |
| Priority date | — |
| Expiry date | Jun 3, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/77
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to an immunizing composition containing an antigenic product such as a multiple antigen peptide system (MAPS) or a filamentous bacteriophage displaying an AβPP epitope spanning the β-secretase cleavage site of AβPP and a method for inducing an immune response against the β-secretase cleavage site of AβPP using this immunizing composition. The present invention is also directed to antibodies against the β-secretase cleavage site of AβPP and their use in a method for inhibiting the formation of amyloid β.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.