Rifamycin analogs and uses thereof

US7494991B2 · kind B2 · utility

Assignee

• ACTIVBIOTICS PHARMA, LLC. · US

Inventors

• John H. van Duzer · Phillipsburg, US
• Arthur F. Michaelis · Devon, US
• William B. Geiss · Athens, US
• Douglas G. Stafford · Niskayuna, US
• Xiang Yu · Acton, US
• James M. Siedlecki · Burlington, US
• Yingfei Yang · Belmont, US

Key dates

• Filing date: May 17, 2007
• Grant date: Feb 24, 2009
• Expiry date: May 17, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3′-hydroxy analogs, and/or various fused ring systems with the benzene ring at the 4′,5′ or 5′,6′ positions.