8-(3-amino-piperidin-1-yl)-7-(but-2-ynyl)-xanthines, the preparation thereof and their use as pharmaceutical compositions

US7495003B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Matthias Eckhardt · Hannover, DE
• Frank Himmelsbach · Mittelbiberach, DE
• Elke Langkopf · Biberach an der Riß, DE
• Mohammad Tadayyon · Hertford, GB
• Leo Thomas · Biberach, DE

Key dates

• Filing date: Sep 1, 2005
• Grant date: Feb 24, 2009
• Expiry date: Oct 18, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The application relates to new substituted xanthines of general formulawherein R1 and R2 are defined as in claims 1 to 11, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).