Xanthine derivatives, their preparation and their use in pharmaceutical compositions

US7495005B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Frank Himmelsbach · Mittelbiberach, DE
• Elke Langkopf · Biberach an der Riß, DE
• Matthias Eckhardt · Hannover, DE
• Michael Mark · Biberach an der Riß, DE
• Roland Maier · Biberach an der Riß, DE
• Ralf Lotz · Schemmerhofen, DE

Key dates

• Filing date: Aug 7, 2003
• Grant date: Feb 24, 2009
• Expiry date: Aug 7, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I)wherein R1 is a phenylcarbonylmethyl group wherein the phenyl moiety is substituted, and R2 to R4 are defined as in the claims, or the prodrugs or salts thereof, particularly the physiologically acceptable salts thereof, pharmaceutical compositions containing these compounds, and methods of treating type I and type II diabetes mellitus, arthritis, obesity, allograft transplantation and calcitonin-induced osteoporosis using these compounds.