Modified nucleotide compounds
US7495088B1 · kind B1 · utility
29Cited by
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3Claims
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Key dates
| Filing date | Jun 28, 1994 |
| Grant date | Feb 24, 2009 |
| Priority date | — |
| Expiry date | Jun 28, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a nuclease resistant nucleotide compound capable of hybridizing with a complementary RNA in a manner which inhibits the function thereof, which modified nucleotide compound includes at least one component selected from the group consisting of MN3M, B(N)xM and M(N)xB wherein N is a phosphodiester-linked modified 2′-deoxynucleoside moiety; M is a moiety that confers endonuclease resistance on said component and that contains at least one modified or unmodified nucleic acid base; B is a moiety that confers exonuclease resistance to the terminus to which it is attached; and x is an integer of at least 2.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.