Process for the preparation of enantiomerically enriched beta amino acid derivatives
US7495123B2 · kind B2 · utility
1Cited by
6References
15Claims
0Family size
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Key dates
| Filing date | Apr 5, 2005 |
| Grant date | Feb 24, 2009 |
| Priority date | — |
| Expiry date | Apr 5, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of an amine-unprotected prochiral beta-amino acrylic acid or derivative thereof in the presence of a rhodium metal precursor complexed with a chiral mono- or bisphosphine ligand.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.