Assay cartridges and methods of using the same

US7497997B2 · kind B2 · utility

Assignee

• MESO SCALE TECHNOLOGIES, LLC. · US

Inventors

• Eli N. Glezer · Del Mar, US
• Jonathan K. Leland · Silver Spring, US
• Mark A. Billadeau · Middletown, US
• Joseph M. Leginus · Silver Spring, US
• Bandele Jeffrey-Coker · Deakins Range, US
• Jeff D. Debad · Gaithersburg, US
• Koustubh A. Phalnikar · Gaithersburg, US
• Sriram Jambunathan · Jersey City, US

Key dates

• Filing date: Dec 23, 2003
• Grant date: Mar 3, 2009
• Expiry date: Nov 12, 2025

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/255
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.