Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies
US7498142B2 · kind B2 · utility
24Cited by
1References
11Claims
0Family size
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Key dates
| Filing date | Jan 31, 2006 |
| Grant date | Mar 3, 2009 |
| Priority date | — |
| Expiry date | Jan 31, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of identifying a combination of antibodies with a combined improved anti tumor activity is provided. The method comprising identifying at least two anti RTK antibodies capable of inducing synergistic endocytosis of the RTK in a cell expressing the RTK, thereby identifying the combination of antibodies with the combined improved anti-tumor activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.