Compounds

US7498326B2 · kind B2 · utility

Assignee

• Glaxo Group Limited · GB

Inventors

• Jeffrey Michael Axten · King of Prussia, US
• Robert A. Daines · Lansdale, US
• David Thomas Davies · Holywell, GB
• Timothy Francis Gallagher · Collegeville, US
• Graham Elgin Jones · Harlow, GB
• William Henry Miller · Collegeville, US
• Neil David Pearson · Harlow, GB
• Israil Pendrak · Collegeville, US

Key dates

• Filing date: Jun 25, 2003
• Grant date: Mar 3, 2009
• Expiry date: Jun 12, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. The piperidine derivatives include compounds of formula (I):wherein RA, AB, n, R3, R2 and R4 are defined herein. For example, RA is an optionally substituted bicyclic carbocyclic or heterocyclic ring system, and R4 is a group U-R5 in which R5 is an optionally substituted bicyclic heterocyclic ring system as defined herein (e.g. optionally substituted pyrido [3,2, -b][1,4] thiazin-yl).