Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same
US7498344B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 15, 2004 |
| Grant date | Mar 3, 2009 |
| Priority date | — |
| Expiry date | Mar 15, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/70
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A pharmaceutical composition, especially a pharmaceutical composition for the alleviation or treatment of symptoms due to ischemic diseases and symptoms derived from seizures, epilepsy, and migraine, and a Ca2+ overload suppressant, containing an arylpiperidinol or arylpiperidine derivative having the formula (I):wherein, R is H, an optionally substituted phenyl, an optionally substituted phenoxy, or an optionally substituted benzoyl, A is a connecting bond, a cycloalkylene, or an alkenylene optionally substituted with a lower alkyl, B is an alkylene optionally substituted with OH or an alkoxy or —NHCO(CH2)n— where n is an integer of 1 to 5, E is a connecting bond, O, or a methylene, X is OH or H provided that when E is O or a methylene, X is not H, and Y and Z are independently H, a halogen, an alkoxy, or an alkyl optionally substituted with a halogen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.