Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof

US7498416B2 · kind B2 · utility

Assignee

• Fibron Limited · IL

Inventors

• Avner Yayon · Afula, IL
• Eran Rom · Rehovot, IL
• Elisabeth Thomassen-Wolf · Birkenfeld, DE
• Eric Borges · Weitensfeld im Gurktal, AT

Key dates

• Filing date: Dec 15, 2003
• Grant date: Mar 3, 2009
• Expiry date: Jun 4, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Molecules comprising the antigen-binding portion of antibodies that block constitutive and/or ligand-dependent activation of a receptor protein tyrosine kinase, such as fibroblast growth factor receptor 3 (FGFR3), are found through screening methods, where a soluble dimeric form of a receptor protein tyrosine kinase is used as target for screening a library of antibody fragments displayed on the surface of bacteriophage. The molecules of the present invention which block constitutive activation can be administered to treat or inhibit skeletal dysplasia, craniosynostosis disorders, cell proliferative diseases or disorders, or tumor progression associated with the constitutive activation of a receptor protein tyrosine kinase.