Synthesis of heteroaryl acetamides from reaction mixtures having reduced water content
US7498439B2 · kind B2 · utility
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23Claims
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Key dates
| Filing date | Jun 3, 2005 |
| Grant date | Mar 3, 2009 |
| Priority date | — |
| Expiry date | Jun 3, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved process for the preparation of a heteroaryl acetamide from a heteroaryl α-hydroxyacetamide is provided. The process comprises directly hydrogenating the heteroaryl α-hydroxyacetamide in the presence of a strong acid, a halide and a catalyst wherein the molar ratio of the starting heteroaryl α-hydroxyacetamide to water at the initiation of hydrogenolysis is at least about 2:1. In one embodiment, the heteroaryl acetamide is zolpidem and the heteroaryl α-hydroxyacetamide is α-hydroxyzolpidem.
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