Immunosuppressive effects of pteridine derivatives

US7501513B2 · kind B2 · utility

Assignee

• 4 AZA Bioscience NV · BE

Inventors

• Mark Waer · Heverlee, BE
• Piet Herdewijn · Heverlee, BE
• Wolfgang Pfleiderer · Konstanz, DE
• Arnaud Marchand · Leuven, BE
• Steven De Jonghe · Brussels, BE

Key dates

• Filing date: Aug 27, 2004
• Grant date: Mar 10, 2009
• Expiry date: Aug 27, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D475/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to a group of trisubstituted and tetrasubstituted pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydro-derivatives and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These compounds are also useful in preventing or treating cardiovascular disorders, allergic conditions, disorders of the central nervous system and cell proliferative disorders.