Method for producing biperiden IV

US7501519B2 · kind B2 · utility

Assignee

• Abbott GmbH & Co. KG · DE

Inventors

• Markus Grosse · Schwetzingen, DE
• Klaus Weber · Ludwigshafen, DE
• Marco Thyes
• Peter Klein · Itzehoe, DE
• Elmar Vilsmaier · Otterbach, DE

Key dates

• Filing date: May 17, 2002
• Grant date: Mar 10, 2009
• Expiry date: May 17, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/108
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a method for producing biperiden by reacting exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenylmagnesium compound. According to the invention, exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone can be obtained by reacting the exo-ether of enol silylene of formula (IV) with a compound of N-methylenepiperidinium.