Non-human transgenic mammal comprising a modified MSP-1 nucleic acid
US7501553B2 · kind B2 · utility
6Cited by
16References
43Claims
0Family size
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Key dates
| Filing date | Feb 20, 2002 |
| Grant date | Mar 10, 2009 |
| Priority date | — |
| Expiry date | Jan 14, 2023 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is known to be difficult to express in cell culture systems, mammalian cell culture systems, or in transgenic animals. The preferred protein candidates for expression using the recombinant techniques of the invention are MSP-1 proteins expressed from DNA coding sequences comprising reduced overall AT content or AT rich regions and/or mRNA instability motifs and/or rare codons relative to the native MSP-1 gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.