Methods of inducing or enhancing connective tissue repair

US7504099B2 · kind B2 · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Dan Gazit · Modiin-Maccabim-Reut, IL
• Gadi Pelled · Los Angeles, US
• Gadi Turgeman · Jerusalem, IL
• Andrea Hoffmann · Hannover, DE
• Peter Eberle · Braunschweig, DE
• Gerhard Gross · Bocholt, DE

Key dates

• Filing date: Dec 30, 2002
• Grant date: Mar 17, 2009
• Expiry date: Jul 2, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2510/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides method for repairing, regenerating, treating, or inducing the repair of an injury, a defect or a condition of a connective tissue of a subject. This invention provides a method of regenerating, enhancing, inducing repair and/or development of connective tissue as a result of a defect, injury or condition of the connective tissue of a subject comprising the step of inserting an engineered cell which comprises a nucleic acid encoding a SMAD protein or variant thereof, so as to induce regeneration, repair and/or development of the connective tissue. This invention further provides methods of ex-vivo implantation of engineered cells into an injury, defect or condition of the connective tissue. This invention also provides a nucleic acid encoding a SMAD 8 protein variant, cells comprising such SMAD 8 variant, include mesenchymal stem cells, progenitor cells or cells derived from a connective tissue. Lastly, this invention provides SMAD 8 protein variant.