N-acylsulfonamide apoptosis promoters

US7504512B2 · kind B2 · utility

Assignee

• Abbott Laboratories · US

Inventors

• David J. Augeri · Princeton, US
• Steven A. Baumeister · South Milwaukee, US
• Milan Bruncko · Libertyville, US
• Daniel A. Dickman · Grayslake, US
• Hong Ding · Gurnee, US
• Jurgen Dinges · Wadsworth, US
• Stephen W. Fesik · Nashville, US
• Philip J. Hajduk · Mundelein, US
• Aaron R. Kunzer · Arlington Heights, US
• William J. McClellan · Waukegan, US
• David G. Nettesheim · Lake Forest, US
• Thorsten Oost · Biberach an der Riß, DE
• Andrew M. Petros · Mundelein, US
• Saul H. Rosenberg · Grayslake, US
• Wang Shen · San Mateo, US
• Sheela A. Thomas · Libertyville, US
• Xilu Wang · Grayslake, US
• Michael D. Wendt · Vernon Hills, US

Key dates

• Filing date: Apr 7, 2004
• Grant date: Mar 17, 2009
• Expiry date: Jan 18, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/74
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

N-Benzoyl arylsulfonamides having the formulaare BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.