Attenuated influenza NS1 variants
US7507411B2 · kind B2 · utility
34Cited by
4References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 11, 2007 |
| Grant date | Mar 24, 2009 |
| Priority date | — |
| Expiry date | Jun 11, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/16161
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Attenuated influenza virus variants comprising substitutions in NS1 that interfere with viral replication and phosphatidylinositol 3-kinase activation are described. NS1 variant polypeptides, polynucleotides encoding NS1 variant polypeptides, a reverse genetics system for producing attenuated influenza virus NS1 variants, immunogenic compositions comprising live attenuated influenza virus NS1 variants, methods of stimulating an immune response against influenza virus, methods of interfering with influenza virus replication, and methods of treating and preventing influenza virus infection are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.