Functional assays that use the T1R3 receptor to screen for taste modulatory compounds
US7507544B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 2, 2003 |
| Grant date | Mar 24, 2009 |
| Priority date | — |
| Expiry date | Oct 3, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Functional assays that use the T1R3 receptor to screen for taste modulatory compounds are provided. These assays include cell-based assays and high throughput functional assays that identify compounds which activate or modulate T1R3 receptor activation. Preferred functional assays detect the effect of a putative taste modulatory compound on intracellular voltage or intracellular calcium of a cell that expresses TIR3 polypeptide, preferably in association with a G protein, e.g. Gdl5. The compounds identified in such functional assays potentially have application as taste modulators and potential flavor enhancers or modulators for additives to foods and beverages for human or animal consumption.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.