Compounds with sulphonamide group and pharmaceutical compositions containing these compounds

US7507725B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Walter Elger · Berlin, DE
• Alexander Hillisch · Solingen, DE
• Annemarie Hedden · Hamburg, DE
• Sigfrid Schwarz · Jena, DE
• Klaus Schollkopf · Berlin, DE

Key dates

• Filing date: May 8, 2001
• Grant date: Mar 24, 2009
• Expiry date: Sep 18, 2021

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to compounds which, acting as a prodrug and/or support, enable an active agent to be taken up by the erythrocytes and/or an active agent to bind to the erythrocytes. The uptake of these compounds by and/or the binding thereof to the erythrocytes is made possible by a group of formula —SO2NR1R2, wherein R1 and R2, independently of each other, mean a hydrogen atom, an acyl group, an alkyl group, a cycloalkyl group, an aryl group, a cyano group or a hydroxy group. The inventive prodrugs enable active agents such as endogenic substances, natural substances and synthetic substances with therapeutically useful properties which have a high “first path” effect, to be administered orally effectively or significantly improve the oral activity thereof.