Antitumor agents

US7507749B2 · kind B2 · utility

Assignee

• Wayne State University · US

Inventors

• Jerome P. Horwitz · Farmington Hills, US
• Stuart T. Hazeldine · Taylor, US
• Thomas H. Corbett · Grosse Pointe Park, US
• Lisa Polin · Oak Park, US

Key dates

• Filing date: May 24, 2007
• Grant date: Mar 24, 2009
• Expiry date: Jul 5, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides compounds of formula I:wherein Y is F, Cl, Br, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agent. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.