Biosynthetic gene cluster for the production of a complex polyketide
US7507752B2 · kind B2 · utility
1Cited by
3References
2Claims
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Key dates
| Filing date | Jun 3, 2005 |
| Grant date | Mar 24, 2009 |
| Priority date | — |
| Expiry date | Jul 9, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided are novel Streptomyces species and methods of modified Streptomyces species. Further described are novel compounds, 36-ketomeridamycin, C9-deoxomeridamycin, and C9-deoxoprolylmeridamcyin and uses thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.