Benzopyran derivatives, method of production and use thereof

US7507761B2 · kind B2 · utility

Assignees

• UNIVERSITE DE LIEGE · BE
• UNIVERSITÉ LIBRE DE BRUXELLES · BE

Inventors

• Sophie Sebille · Huy, BE
• Bernard Pirotte · Liège, BE
• Stéphane Boverie · Hirson, FR
• Pascal De Tullio · Jupille, BE
• Philippe Lebrun · Vieusart, BE
• Marie-Hélène Antoine · Brussels, BE

Key dates

• Filing date: Jan 21, 2005
• Grant date: Mar 24, 2009
• Expiry date: Mar 31, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel benzopyran derivatives of formula I, to their method of production, to composition comprising the derivatives and use thereof.wherein:R1, R2, R3 and R4 are independently hydrogen, halogen, C1-6-alkyl, C3-8-cycloalkyl, hydroxy, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, nitro, amino, cyano, cyanomethyl, perhalomethyl, C1-6-monoalkyl- or dialkylamino, sulfamoyl, C1-6-alkylthio, C1-6-alkylsulfonyl, C1-6-alkylsulfinyl, formyl, C1-6-alkylcarbonylamino, R8arylthio, R8arylsulfinyl, R8arylsulfonyl, C1-6-alkoxycarbonyl, C1-6-alkoxycarbonyl-C1-6-alkyl, carbamoyl, carbamoylmethyl, C1-6-monoalkyl- or dialkylaminocarbonyl, C1-6-monoalkyl- or dialkylaminothiocarbonyl, ureido, C1-6-monoalkyl- or dialkylaminocarbonylamino, thioureido, C1-6-monoalkyl- or dialkylaminothiocarbonylamino, C1-6-monoalkyl- or dialkylaminosulfonyl, carboxy, carboxy-C1-6-alkyl, acyl, R8aryl, R8aryl-C1-6-alkyl, R8aryloxy;R5 and R6 are each independently hydrogen, C1-6-alkyl or, R5 and R6 taken together with the carbon atom to which they are attached form a 3- to 6-membered carbocyclic ring;R7 is 2-, 3- or 4-pyridyl optionally mono- or polysubstituted by R1;R7 is 2- or 3-thienyl optionally mono- or p…