Triazole PPAR modulators

US7507832B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Nathan B. Mantlo · Westfield, US
• Antonio Navarro · Indianapolis, US
• Ashraf Saeed · Carmel, US
• Douglas Linn GERNERT · Indianapolis, US
• Tianwei Ma · Carmel, US
• Lance Allen Pfeifer · Indianapolis, US

Key dates

• Filing date: Dec 21, 2004
• Grant date: Mar 24, 2009
• Expiry date: Jan 12, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D285/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to compounds represented by the following structural formula, Formula (I): wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of O, C, S, NH and a single bond; (d) W is N, O or S; (e) E is C(R3)(R4)A or A and wherein; (f) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamide, sulfonamide and acylsufonamide. The other substituents are defined in the claims; the compounds are modulators of peroxisome proleferator activated receptors (PPARs) and are useful for the treatment of diabetes and other metabolic disorders.